{"id":42,"date":"2016-04-15T11:50:33","date_gmt":"2016-04-15T02:50:33","guid":{"rendered":"http:\/\/professors.matsumoto-u.ac.jp\/yamada\/wordpress\/?page_id=42"},"modified":"2016-04-15T11:50:33","modified_gmt":"2016-04-15T02:50:33","slug":"%e7%a0%94%e7%a9%b6%e3%83%86%e3%83%bc%e3%83%9e","status":"publish","type":"page","link":"http:\/\/professors.matsumoto-u.ac.jp\/yamada\/?page_id=42&lang=ja","title":{"rendered":"\u7814\u7a76\u30c6\u30fc\u30de"},"content":{"rendered":"<h3>\u6804\u990a\u7d20\u3068\u30db\u30eb\u30e2\u30f3\u306b\u3088\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0<\/h3>\n<p>\u9ad8\u70ad\u6c34\u5316\u7269\u6442\u98df\u5f8c\u306e\u30e9\u30c3\u30c8\u809d\u81d3\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308a\u8ee2\u5199\u304c\u4fc3\u9032\u3055\u308c\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001basic helix-loop-helix \u578b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b SHARP-2 (DEC1, Stra13, BHLHB2 \u3068\u3082\u3044\u3046)\u3092\u540c\u5b9a\u3057\u3066\u3044\u308b\u3002\u57f9\u990a\u7d30\u80de\u306b\u304a\u3051\u308b SHARP-2 \u306e\u904e\u5270\u767a\u73fe\u306b\u3088\u308a\u3001\u8840\u7cd6\u4e0a\u6607\u306b\u95a2\u308f\u308b\u7cd6\u65b0\u751f\u7cfb\u9175\u7d20\u3067\u3042\u308b\u30db\u30b9\u30db\u30a8\u30ce\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\u30ab\u30eb\u30dc\u30ad\u30b7\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001SHARP-2 \u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u3092\u4ecb\u5728\u3059\u308b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u306e\u4e00\u3064\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002\u73fe\u5728\u3001SHARP-2 \u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u691c\u7d22\u3068 SHARP-2 \u306b\u3088\u308b\u8ee2\u5199\u8abf\u7bc0\u6a5f\u69cb\u306e\u89e3\u6790\u306a\u3089\u3073\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b SHARP-2 \u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u4fc3\u9032\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<h3>\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6d3b\u6027\u3092\u6709\u3059\u308b\u98df\u54c1\u6210\u5206\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u6790<\/h3>\n<p>\u79c1\u3069\u3082\u306f\u3001SHARP \u30d5\u30a1\u30df\u30ea\u30fc\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6307\u6a19\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u30b2\u30cb\u30b9\u30c6\u30a4\u30f3\u3084\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306e(-)-epigallocatechin-3-gallete( EGCG )\u3092\u3001\u7cd6\u5c3f\u75c5\u4e88\u9632\u52b9\u679c\u3092\u671f\u5f85\u3067\u304d\u308b\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3068\u3057\u3066\u540c\u5b9a\u3057\u3066\u3044\u308b\u3002<br \/>\n\u73fe\u5728\u3001SHARP \u30d5\u30a1\u30df\u30ea\u30fc\u907a\u4f1d\u5b50\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8840\u7cd6\u4f4e\u4e0b\u4f5c\u7528\u306e\u76f4\u63a5\u7684\u306a\u56e0\u5b50\u3067\u3042\u308b\u30db\u30b9\u30db\u30a8\u30ce\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\u30ab\u30eb\u30dc\u30ad\u30b7\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u6291\u5236\u3092\u6307\u6a19\u306b\u98df\u54c1\u6210\u5206\u304b\u3089\u5e83\u304f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001\u6297\u7cd6\u5c3f\u75c5\u52b9\u679c\u3092\u6709\u3059\u308b\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3092\u691c\u7d22\u3057\u3066\u3044\u308b\u3002<\/p>\n<h3>\u767a\u764c\u306b\u3088\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0<\/h3>\n<p>Zinc-fingers and homeoboxes (ZHX) \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001\u30d2\u30c8 ZHX1, ZHX2 \u304a\u3088\u3073 ZHX3 \u306e 3 \u3064\u306e\u8ee2\u5199\u6291\u5236\u56e0\u5b50\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u540c\u5b9a\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u3001\u3059\u3079\u3066\u4e92\u3044\u306b\u30db\u30e2\u30fb\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3001\u7d30\u80de\u5897\u6b96\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b Nuclear factor-Y \u306e A \u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001NF-Y \u4f9d\u5b58\u7684\u306a\u8ee2\u5199\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u308b\u3002\u7d30\u80de\u5897\u6b96\u3068 ZHX \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3068\u306e\u95a2\u4fc2\u3084 ZHX \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u6291\u5236\u6a5f\u69cb\u306e\u89e3\u6790\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<h3>\u30d2\u30c8 II \u578b\u7cd6\u5c3f\u75c5\u539f\u56e0\u5019\u88dc\u907a\u4f1d\u5b50\u306e\u63a2\u7d22(\u5171\u540c\u7814\u7a76)<\/h3>\n<p>\u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u306e\u5927\u6fa4\u6625\u5f66\u6559\u6388\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u30d2\u30c8\u30ec\u30b8\u30b9\u30c1\u30f3\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306e\u5358\u4e00\u5869\u57fa\u591a\u578b\u304c\u65e5\u672c\u4eba\u306e II \u578b\u7cd6\u5c3f\u75c5\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u305f\u3002\u3053\u306e\u5869\u57fa\u3092\u6709\u3059\u308b\u30d2\u30c8\u3067\u306f\u3001\u8ee2\u5199\u56e0\u5b50 Sp1\/Sp3 \u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u6b63\u5e38\u306a\u30d2\u30c8\u306b\u6bd4\u3079\u3066\u30ec\u30b8\u30b9\u30c1\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u3082\u3001\u65e5\u672c\u4eba\u306e II \u578b\u7cd6\u5c3f\u75c5\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6804\u990a\u7d20\u3068\u30db\u30eb\u30e2\u30f3\u306b\u3088\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0 \u9ad8\u70ad\u6c34\u5316\u7269\u6442\u98df\u5f8c\u306e\u30e9\u30c3\u30c8\u809d\u81d3\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308a\u8ee2\u5199\u304c\u4fc3\u9032\u3055\u308c\u308b\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3001basic helix-loop-helix \u578b\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b SHARP-2 (DEC1, Stra13, BHLHB2 \u3068\u3082\u3044\u3046)\u3092\u540c\u5b9a\u3057\u3066\u3044\u308b\u3002\u57f9\u990a\u7d30\u80de\u306b\u304a\u3051\u308b SHARP-2 \u306e\u904e\u5270\u767a\u73fe\u306b\u3088\u308a\u3001\u8840\u7cd6\u4e0a\u6607\u306b\u95a2\u308f\u308b\u7cd6\u65b0\u751f\u7cfb\u9175\u7d20\u3067\u3042\u308b\u30db\u30b9\u30db\u30a8\u30ce\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\u30ab\u30eb\u30dc\u30ad\u30b7\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001SHARP-2 \u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u3092\u4ecb\u5728\u3059\u308b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u306e\u4e00\u3064\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002\u73fe\u5728\u3001SHARP-2 \u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u691c\u7d22\u3068 SHARP-2 \u306b\u3088\u308b\u8ee2\u5199\u8abf\u7bc0\u6a5f\u69cb\u306e\u89e3\u6790\u306a\u3089\u3073\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b SHARP-2 \u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u4fc3\u9032\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u884c\u3063\u3066\u3044\u308b\u3002 \u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6d3b\u6027\u3092\u6709\u3059\u308b\u98df\u54c1\u6210\u5206\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u4f5c\u7528\u6a5f\u69cb\u306e\u89e3\u6790 \u79c1\u3069\u3082\u306f\u3001SHARP \u30d5\u30a1\u30df\u30ea\u30fc\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6307\u6a19\u306b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u5927\u8c46\u30a4\u30bd\u30d5\u30e9\u30dc\u30f3\u306e\u30b2\u30cb\u30b9\u30c6\u30a4\u30f3\u3084\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306e(-)-epigallocatechin-3-gallete( EGCG )\u3092\u3001\u7cd6\u5c3f\u75c5\u4e88\u9632\u52b9\u679c\u3092\u671f\u5f85\u3067\u304d\u308b\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3068\u3057\u3066\u540c\u5b9a\u3057\u3066\u3044\u308b\u3002 \u73fe\u5728\u3001SHARP \u30d5\u30a1\u30df\u30ea\u30fc\u907a\u4f1d\u5b50\u3084\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308b\u8840\u7cd6\u4f4e\u4e0b\u4f5c\u7528\u306e\u76f4\u63a5\u7684\u306a\u56e0\u5b50\u3067\u3042\u308b\u30db\u30b9\u30db\u30a8\u30ce\u30fc\u30eb\u30d4\u30eb\u30d3\u30f3\u9178\u30ab\u30eb\u30dc\u30ad\u30b7\u30ad\u30ca\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u6291\u5236\u3092\u6307\u6a19\u306b\u98df\u54c1\u6210\u5206\u304b\u3089\u5e83\u304f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001\u6297\u7cd6\u5c3f\u75c5\u52b9\u679c\u3092\u6709\u3059\u308b\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3092\u691c\u7d22\u3057\u3066\u3044\u308b\u3002 \u767a\u764c\u306b\u3088\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u8abf\u7bc0 Zinc-fingers and homeoboxes (ZHX) \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u3001\u30d2\u30c8 ZHX1, ZHX2 \u304a\u3088\u3073 ZHX3 \u306e 3 \u3064\u306e\u8ee2\u5199\u6291\u5236\u56e0\u5b50\u3092\u4e16\u754c\u3067\u521d\u3081\u3066\u540c\u5b9a\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u3001\u3059\u3079\u3066\u4e92\u3044\u306b\u30db\u30e2\u30fb\u30d8\u30c6\u30ed\u4e8c\u91cf\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u3001\u7d30\u80de\u5897\u6b96\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308b Nuclear factor-Y \u306e A \u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3001NF-Y \u4f9d\u5b58\u7684\u306a\u8ee2\u5199\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u308b\u3002\u7d30\u80de\u5897\u6b96\u3068 ZHX \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3068\u306e\u95a2\u4fc2\u3084 ZHX \u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u6291\u5236\u6a5f\u69cb\u306e\u89e3\u6790\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002 \u30d2\u30c8 II \u578b\u7cd6\u5c3f\u75c5\u539f\u56e0\u5019\u88dc\u907a\u4f1d\u5b50\u306e\u63a2\u7d22(\u5171\u540c\u7814\u7a76) \u611b\u5a9b\u5927\u5b66\u533b\u5b66\u90e8\u306e\u5927\u6fa4\u6625\u5f66\u6559\u6388\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u3001\u30d2\u30c8\u30ec\u30b8\u30b9\u30c1\u30f3\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306e\u5358\u4e00\u5869\u57fa\u591a\u578b\u304c\u65e5\u672c\u4eba\u306e II \u578b\u7cd6\u5c3f\u75c5\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u4e00\u3064\u3067\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u305f\u3002\u3053\u306e\u5869\u57fa\u3092\u6709\u3059\u308b\u30d2\u30c8\u3067\u306f\u3001\u8ee2\u5199\u56e0\u5b50 Sp1\/Sp3 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