研究業績

2024年

【原著】

  1. Yamada, K., Aoki, M., Koitabashi, H., Misaki, T., Shiotani, K., Honzawa, S., Kobayashi, M., Koide, K., Wada, M., Kosuda, Y., Nishizawa, A., Takagi, N., Miyashita, M., Isshi, Y., Tsukada, A., and Takagi, K.: Gene expression of SHARP-2 is induced by transforming growth factor beta via multiple pathways in HuH-7 hepatoma cells. (2024) J. Matsumoto Univ.  22, 97-106. (PDF).

【その他】

    1. 山田一哉、三崎紀展、塩谷一紗、吉田瀬七、田中高志、冨田晃司：マウス3T3-L1脂肪細胞における各種転写因子遺伝子の発現調節と標的遺伝子の検索．(2024)松本大学研究紀要 22, 249-251.(PDF).

2023年

【その他】

    1. 山田一哉、三崎紀展、吉田瀬七、小野萌、田中高志、冨田晃司:3T3-L1脂肪細胞におけるcAMP系によるZHX2遺伝子の発現誘導機構の解析と標的遺伝子の検索。(2023) 松本大学研究紀要 21, 173-176.(PDF).

2022年

【原著】

  1. Yamada, K., Mishima, A., Hanaoka, Y., Misaki, T., Kamijo, A., Sakamoto, N., Chino, Y., Horiuchi, S., Kondo, H., Nagai, A., Maruyama, Y., Yamane, Y., Tanokuchi, A., Tsukada, A., and Takagi, K.: Identification and characterization of the SHARP-2-interacting proteins. (2022) J. Matsumoto Univ.  20, 105-115　(PDF).

2021年

【総説】

1. 三崎紀展、林桃子、髙木勝広、山田一哉:ビタミン A 誘導体による時計遺伝子・血糖調節遺伝子の発現制御。(2021) New Food Industry 63, 501-508.

【原著】

  1. Miyakawa, M., Kubo, S., Tada, A., Konno, N., Oda, H., Tanaka, M., Saito, S., Aoki, Y., and Yamada, K.: Effects of bovine lactoferrin on subjective gastrointestinal symptoms related to physical conditions in healthy subjects: a randomized, double-blind, placebo-controlled trial. 49, 2187-2193 (2021) Jpn. Pharmacol. Ther.  49, 2187-2193.
  2. Hayashi, M., Misaki, T., Yoshida, S., Tokutake, H., Aruga, T., Yoda, K., Kenmochi, E., Saito, K., Togashi, M., Nakano, M., Maejima, M., Amemiya, R., Sakuma, A., Nakazawa, Y., Takagi, K., Tsukada, A., and Yamada, K.: Retinoic acid stimulates transcription of the rat SHARP-2 gene via multiple pathways. (2021) J. Biochem.  170, 427-434.

2020年

【総説】

1. 塚田晃子、髙木勝広、山田一哉:インスリン誘導性 SHARP-1 遺伝子と SIRT1 遺伝子の発現相関。(2020) New Food Industry 62, 339-345.

【原著】

  1. Asano, K., Tsukada, A., Yanagisawa, Y., Higuchi, M., Takagi, K., Ono, M., Tanaka, T., Tomita, K., and Yamada K.: Melatonin stimulates transcription of the rat phosphoenolpyruvate carboxykinase gene in the hepatic cells. (2020) FEBS Open Bio.  10, 2712-2721 (PDF).
  2. Asano, K., Tsukada, A., Takagi, K., and Yamada K.: An insulin-inducible transcription factor, SHARP-1, repersses transcription of the SIRT1 longevity gene. (2020) Biochem. Biophys. Rep.  22, 1-6 (PDF).

2018年

【著書】

      1. 山田一哉: 8章「糖質，脂質，タンパク質と遺伝子発現」栄養科学シリーズNEXT「分子栄養学」（宮本賢一・井上裕康・桑波田雅士、金子一郎編）（2018）pp.86-pp.97　講談社サイエンティフィック．

    2017年

    【総説】

    1. 塚田晃子、髙木勝広、浅野公介、山田一哉:インスリン誘導性時計遺伝子 SHARP ファミリーの発現調節機構。(2017) New Food Industry 59, 1-10.

    【原著】

      1. Alkelai, A., Olender, T., Dode, C., Shushan, S, Tatarskyy, P., Furman-Haran, E., Boyko, V., Gross-Isseroff, R., Halvorsen, M., Greenbaum, L., Milgrom, R., Yamada K., Haneishi, A., Milgrom, R., Blau, I., and Lancet, D.: Next-generation sequencing of patients with congenital anosmia. (2017) Eur. J. Hum. Genet.  25, 1377-1387.
      2. Aoki, Y., Aoki, M., and Yamada, K.: Leukocyte telomere length and serum levels of high-molecular-weight adiponectin and dehydroepiandrosterone-sulfate could reflect distinct aspects of longevity in Japanese centenarians. (2017) Gerontol. Geriatr. Med. 3, 1-6.
      3. Kanai, Y., Asano, K., Komatsu, Y., Takagi, K., Ono, M., Tanaka, T., Tomita, K., Haneishi, A., Tsukada, A., and Yamada, K.: Induction of the SHARP-2 mRNA level by insulin is mediated by multiple signaling pathways. (2017) Biosci. Biotech. Biochem. 81, 256-261 (PDF).

    2016年

    【原著】

        1. Kawamura, R., Tabara, Y., Tsukada, A., Igase, M., Ohashi, J., Yamada, R., Takata, Y., Kawamoto, R., Saito, I., Onuma, H., Tanigawa, T., Yamada, K., Kato, N., Ohyagi, Y., Miki, T., Kohara, K., and Osawa, H.: A genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population. (2016) Physiol. Genom. 48, 874-881.
        2. Komatsu, Y., Yanagisawa, Y., Moriizumi, M., Tsuchiya, Y., Yokouchi, H., Otsuka, H., Aoyagi, M., Tsukada, A., Kanai, Y., Haneishi, A., Takagi, K., Asano, K., Ono, M., Tanaka, T., Tomita, K., and Yamada, K.: 5-aminoimidazole-4-carboxyamide-1-beta-D-ribofranoside stimulates the rat enhancer of split- and hairy-related protein-2 gene via atypical protein kinase C lambda. (2016) J. Biochem. 159,429-436 (PDF).

    2015年以前

    【著書】

        1. 山田一哉:第17章.「遺伝子の発現と制御」第18章.「栄養と遺伝子・遺伝子組み換え技術」管理栄養士養成課程『栄養管理と生命科学シリーズ』「化学・生化学」(大村正史、本美保子、山田一哉編) pp.249-pp.281 理工図書 (2011).
        2. 高木勝広:第3章.微生物学の基礎。管理栄養士養成課程『栄養管理と生命科学シリーズ』「食品衛生の科学」(熊田薫、後藤政幸、桜井直美編) pp.23-pp.36 理工図書 (2011).
        3. 山田一哉、野口民夫:「遺伝子発現と栄養」。新臨床栄養学増補版(岡田正、馬場忠雄、山城雄一郎編) pp. 155-pp.163 医学書院 (2011).
        4. 山田一哉:「基礎からのやさしい化学ーヒトの健康と栄養を学ぶためにー」(田島 眞編) pp.3-25, pp.53-59 建帛社 (2011).
        5. 山田一哉:第5章.遺伝のしくみ。「生物学ーヒトと環境の生命科学」(川崎祥二、古庄 律編) pp.105-pp.128 建帛社 (2009).
        6. 山田一哉、野口民夫:「遺伝子発現と栄養」。新臨床栄養学(岡田正、馬場忠雄、山城雄一郎編) pp. 155-pp.162 医学書院 (2007).
        7. 山田一哉:「2.糖質」。栄養・食糧学データハンドブック(日本栄養・食糧学会編) pp.55-pp.56 同文書院 (2005).
        8. 山田一哉、野口民夫:「生合成、分解とその調節機構」。臨床アルブミン学(渡邊明治編) pp.39-pp.45 メディカルレビュー社 (1999).
        9. 山田一哉、野口民夫:「fusion gene とアフィニティカラムを用いた蛋白精製方法」。日本臨床(特別号):臨床分子生物学(村松正寶編) 52: 440-443 (1994).

    【総説】

        1. 髙木勝広、浅野公介、羽石歩美、山田一哉:ホルモンと食品成分による時計遺伝子 SHARPs の発現調節機構。(2015) New Food Industry 57, 7-18.
        2. 羽石歩美、髙木勝広、浅野公介、山田一哉:腸内細菌代謝産物によるインスリン誘導性遺伝子の発現制御。(2014) New Food Industry 56, 57-65.
        3. 浅野公介、髙木勝広、羽石歩美、山田一哉:緑茶カテキンによるインスリン誘導性転写因子遺伝子 SHARP-1 の発現調節機構の解析。(2012) New Food Industry 54, 37-45.
        4. 羽石歩美、髙木勝広、浅野公介、山田一哉:ゲニステインによるインスリン誘導性転写因子 SHARP-2 の発現調節機構の解析。(2011) New Food Industry 53, 1-8.
        5. Yamada, K. and Miyamoto, K.: Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli. (2005) Front. Biosci. 10, 3151-3171 (PDF).
        6. Yoshino, M., Mizutani, T., Yamada, K., Arima, T., Yazawa, T., Ogata-Kawata, H., Sekiguchi, T., Kajitani, T., and Miyamoto, K.: Characterization of two FSH inducible genes, a nuclear transcriptional co-activator p120 and a novel serine protease-like protein, in the rat ovarian granulosa cells. (2004) Jpn. J. Reprod. Endocrinol. 9, 29-34.
        7. 山田一哉、野口民夫:糖脂質代謝酵素遺伝子発現の糖反応性エレメント。(2004) Diabetes Frontier 15: 189-193.
        8. 山田一哉:新しい転写因子ファミリー:ZHX。(2004) 生体の科学 55: 274.
        9. 山田一哉、野口民夫:転写因子 Sterol regulatory element-binding protein (SREBP) と糖質・脂質代謝。(2002) 日本栄養食糧学会誌 55: 45-50.
        10. 山田一哉、野口民夫:炭水化物による遺伝子の発現調節機構。(2001) 小児科診療 64: 667-673.
        11. Yamada, K. and Noguchi, T.: Nutrient and hormonal regulation of pyruvate kinase gene expression. (1999) Biochem. J. 337, 1-11 (PDF).
        12. Yamada, K. and Noguchi, T.: Regulation of pyruvate kinase M gene expression. (1999) Biochem. Biophys. Res. Commun. 256, 257-262.
        13. 山田一哉、野口民夫:炭水化物による遺伝子の発現調節機構 (1999) 日本栄養食糧学会誌 52: 167-173.
        14. 山田一哉、野口民夫:炭水化物による遺伝子発現制御。ピルビン酸キナーゼとインスリン遺伝子について。(1998)日本農芸化学会誌 72: 1063-1066.
        15. 山田一哉、野口民夫:細胞の分化および癌化に伴うアイソザイム遺伝子の発現変換。(1995)日本臨床 53: 1112-1118.
        16. 山田一哉、野口民夫:哺乳動物ピルビン酸キナーゼの構造と代謝制御。(1993) 細胞工学 12: 895-901.

    【原著】

      1. Takagi, K., Asano, K., Haneishi, A., Ono, M., Komatsu, Y., Yamamoto, T., Tanaka, T., Ueno, H., Ogawa, W., Tomita, K., Noguchi, T., and Yamada, K.: Insulin stimulates the expression of the SHARP-1 gene via multiple signaling pathways. (2014) Horm. Metab. Res. 46, 397-403.
      2. Asano, K., Takagi, K., Haneishi, A., Nakamura, S., and Yamada, K.: (-)-Epigallocatechin-3-gallate stimulates both AMP-activated protein kinase and nuclear factor-kappa B signaling pathways. (2012) Food Chem. 134, 783-788.
      3. Haneishi, A., Takagi, K., Asano, K., Yamamoto, T., Tanaka, T., Nakamura, S., Noguchi, T., and Yamada, K.: Analysis of regulatory mechanisms of an insulin-inducible SHARP-2 gene by (S)-Equol. (2012) Arch. Biochem. Biophys. 525, 32-39.
      4. Haneishi, A., Takagi, K., Asano, K., Nakamura, S., and Yamada, K.: Analysis of induction mechanisms of an insulin-inducible transcription factor SHARP-2 gene　by (-)-Epigallocatechin-3-gallate. (2012) J. Agric. Food Chem. 60, 9850-9855.
      5. Haneishi, A., Takagi, K., Asano, K., Nakamura, S., Kagawa, N., and Yamada, K.: Genistein stimulates the insulin-signaling pathway. (2011) Front. Biosci. E3, 1534-1540 (PDF).
      6. Asano, K., Takagi, K., Haneishi, A., Yamamoto, T., Tanaka, T., Noguchi, T., Nakamura, S., and Yamada, K.: (-)-Epigallocatechin-3-gallate enhances the expression of an insulin-inducible transcription factor gene via a phosphoinositide 3-kinase/ atypical protein kinase C lambda pathway. (2011) J. Agric. Food Chem. 59, 13360-13364.
      7. Onuma, H., Tabara, Y., Kawamura, R., Tanaka, T., Ohashi, J., Nishida, W., Takata, Y., Ochi, M., Yamada, K., Kawamoto, R., Kohara, K., Miki, T., Makino, H., and Osawa, H.: A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population. (2010) PLoS ONE 5, e9718.
      8. Yamada, K., Ogata-Kawata, H., Matsuura, K., Kagawa, N., Takagi, K., Asano, K., Haneishi, A., and Miyamoto, K.: ZHX2 and ZHX3 repress cancer markers in normal hepatocytes. (2009) Front. Biosci. 14, 3724-3732 (PDF).
      9. Shou, Z., Xiao, H., Xu, Y., Yang, Y., Jiang, H., Chen, J., Yamada, K., and Miyamoto, K.: SHARP-2 gene silencing by lentiviral-based short hairpin RNA interference prolonged rat kidney transplant recipients’ survival time. (2009) J. Int. Med. Res. 37, 766-778.
      10. Osawa, H., Tabara, Y., Kawamoto, R., Ohashi, J., Ochi, M., Onuma, H., Nishida, W., Yamada, K., Nakura, J., Miki, T., Makino, H., and Kohara, K.: The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. (2009) Clin. Endocrinol. 71, 341-345.
      11. Shou, Z., Zhou, Q., Cai, J.-R., Chen, J.-H., Yamada, K., and Miyamoto, K.: PI 3-kinase pathway can mediate the effect of TGF-beta1 in inducing the expression of SHARP-2 in LLC-PK1 cells. (2009) J. Zhejiand Univ. Sci. B. 10, 702-706.
      12. Zenimaru, Y., Takahashi, S., Takahashi, M., Yamada, K., Iwasaki, T., Hattori, H., Imagawa, M., Ueno, M., Suzuki, J., and Miyamori, I.: Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells. (2008) Biochem. Biophys. Res. Commun. 318, 716-722.
      13. Inaoka, Y., Yazawa, T., Uesaka, M., Mizutani, T., Yamada, K., and Miyamoto, K.: Regulation of NGFI-B/ Nurr77 gene expression in the rat ovary and Leydig tumour cells MA-10. (2008) Mol. Reprod. Dev. 75, 931-939.
      14. Osawa, H., Yamada, K., Tabara, Y., Ochi, M., Onuma, H., Nishida, W., Shimizu, I., Kawamoto, R., Fujii, Y., Miki, T., Ohashi, J., and Makino, H.: The G/G genotype of a single nucleotide polymorphism at -1066 of c-Jun N-terminal kinase 1 gene (MAPK8) does not affect type 2 diabetes susceptibility despite the specific binfding of AP2alpha. (2008) Clin. Endocrinol. 69, 36-44.
      15. Ogata-Kawata, H., Yamada, K., Uesaka-Yoshino, M., Kagawa, N., and Miyamoto, K.: BS69, a corepressor interacting with ZHX1, is a bifunctional transcription factor. (2007) Front. Biosci. 12, 1911-1926 (PDF).
      16. Satoh, S., Masatoshi, S., Shou, Z., Yamamoto, T., Ishigure, T., Semii, A., Yamada, K., and Noguchi, T.: Identification of cis-regulatory elements and trans-acting proteins of the rat carbohydrate response element binding protein gene. (2007) Arch. Biochem. Biophys. 461, 113-122 (PDF).
      17. Osawa, H., Tabara, Y., Kawano, R., Ohashi, J., Ochi, M., Onuma, H., Nishida, W., Yamada, K., Nakura, J., Kohara, K., Miki, T., and Makino, H.: Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL, and high sensitivity CRP in the Japanese general population. (2007) Diabetes Care 30, 1501-1506.
      18. Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Yoshino, M., Kajitani, T., Shou, Z., Umezawa, A., and Miyamoto, K.: Differentiation of adult stem cells derived from bone marrow stroma into Leydig or adrenocortical cells. (2006) Endocrinology 147, 4112-4121.
      19. Yoshino, M., Mizutani, T., Yamada, K., Yazawa, T., Kawata, H., Sekiguchi, T., Kajitani, T., and Miyamoto, K.: Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity. (2006) Reprod. Biol. & Endocrinol. 4, 50.
      20. Sato, S., Noaki, T., Ishigure, T., Osada, S., Imagawa, M., Miura, N., Yamada, K., and Noguchi, T.: Nuclear factor 1 family members interact with hepatocyte nuclear factor 1a to synergistically activate L-type pyruvate kinase gene transcription. (2005) J. Biol. Chem. 280, 39827-39834 (PDF).
      21. Osawa, H., Onuma, H., Ochi, M., Murakami, A., Yamauchi, J., Takasuka, T., Tanabe, F., Shimizu, I., Kato, K., Nishida, W., Yamada, K., Tabara, Y., Yasukawa, M., Fujii, Y., Ohashi, J., Miki, T., Makino, H.: Resistin SNP-420 determines its monocytes mRNA and serum levels inducing type 2 diabetes. (2005) Biochem. Biophys. Res. Commun. 335, 596-602.
      22. Yamada, K., Ogata-Kawata, H., Matsuura, K., and Miyamoto, K.: SHARP-2/ Stra13/ DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression. (2005) FEBS Lett. 579, 1509-1514 (PDF).
      23. Osawa, H., Yamada, K., Onuma, H., Murakami, A., Ochi, M., Kawata, H., Nishimiya, T., Niiya, T., Shimizu, I., Nishida, W., Hashiramoto, M., Kanatsuka, A., Fujii, Y., Ohashi, J., and Makino, H.: The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3. (2004) Am. J. Hum. Genet. 75, 678-686 (PDF).
      24. Kawata, H., Yamada, K., Matsuura, K., Shou, Z., and Miyamoto, K.: Insulin regulates the expression of the enhancer of split- and hairy-related protein-2 gene via different pathways in 3T3-L1 adipocytes and L6 myotubes. (2004) Horm. Metab. Res. 36, 526-530 (PDF).
      25. Sekiguchi, T., Mizutani, T., Yamada, K., Kajitani, T., Yazawa, T., Yoshino, M., and Miyamoto, K.: Expression of epiregulin and amphiregulin in the rat ovary. (2004) J. Mol. Endocrinol. 33, 281-291.
      26. Kajitani, T., Mizutani, T., Yamada, K., Yazawa, T., Sekiguchi, T., Yoshino, M., Kawata, H., and Miyamoto, K.: Cloning and characterization of GCX-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. (2004) Endocrinol. 145, 2307-2318.
      27. Sato, A., Keng, V. W., Yamamoto, T., Kasamatsu, S., Ban, T., Tanaka, H., Satoh, S., Yamada, K., and Noguchi, T.: Identification and characterization of the hematopoietic cell-specific enhancer element of the mouse Hex gene. (2004) J. Biochem. (Tokyo) 135, 259-268.
      28. Shou, Z., Yamada, K., Kawata, H., Yokoyama, O., and Miyamoto, K.: A mechanism of induction of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene expression by interleukin-2. (2004) Biochem. Biophys. Res. Commun. 314, 885-890 (PDF).
      29. Hirano, S., Yamada, K., Kawata, H., Shou, Z., Mizutani, T., Shigematsu, Y., Mayumi, M., and Miyamoto, K.: The rat enhancer of split- and hairy-related protein-2 gene: hepatic expression, genomic structure, and promoter analysis. (2004) Arch. Biochem. Biophys. 422, 81-90 (PDF).
      30. Yamada, K., Kawata, H., Mizutani, T., Arima, T., Yazawa, T., Matsuura, K., Shou, Z., Sekiguchi, T., Yoshino, M., Kajitani, T., and Miyamoto, K.: Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells. (2004) Biol. Reprod. 70, 76-82 (PDF).
      31. Kawata, H., Yamada, K., Shou, Z., Mizutani, T., and Miyamoto, K.: The mouse zinc-fingers and homeoboxes (ZHX) family: ZHX2 forms a heterodimer with ZHX3. (2003) Gene 323, 133-140 (PDF).
      32. Yamada K., Kawata, H., Shou, Z., Mizutani, T., Noguchi, T., and Miyamoto, K.: Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway. (2003) J. Biol. Chem. 278, 30719-30724 (PDF).
      33. Kawata, H., Yamada, K., Shou, Z., Mizutani, T., Yazawa, T., Yoshino, M., Sekiguchi, T., Kajitani, T., and Miyamoto, K.: Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. (2003) Biochem. J. 373, 747-757 (PDF).
      34. Asai, Y., Yamada, K., Watanabe, T., Keng, V. W., and Noguchi, T.: Insulin stimulates expression of pyruvate kinase M gene in 3T3-L1 adipocytes. (2003) Biosci. Biotechnol. Biochem. 67, 1272-1277.
      35. Yamada, K., Kawata, H., Shou, Z., Hirano, S., Mizutani, T., Yazawa, T., Sekiguchi, T., Yoshino, M., Kajitani, T., and Miyamoto, K.: Analysis of zinc-fingers and homeoboxes (ZHX) 1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. (2003) Biochem. J. 373, 167-178 (PDF).
      36. Osawa, H., Niiya, T., Onuma, H., Murakami, A., Ochi, M., Nishimiya, T., Ogura, T., Kato, K., Shimizu, I., Fujii, Y., Ohashi, J., Yamada, K., Liang, S.-J., Manganiello, V. C., Fujita-Yamaguchi, Y., and Makino, H.: Systematic search for single nucleotide polymorphisms in the 5′ flanking region of the human phosphodiesterase 3B gene: absence of evidence for major effects of identified polymorphisms on susceptibility to Japanese type 2 diabetes. (2003) Mol. Genet. Metab. 79, 43-51.
      37. Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Yoshino, M., Kajitani, T., Shou, Z., and Miyamoto, K.: Involvement of cyclic adenosine 5′-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells. (2003) Endocrinol. 144, 1920-1930.
      38. Shou, Z., Yamada, K., Inazu, T., Kawata, H., Hirano, S., Mizutani, T., Yazawa, T., Sekiguchi, T., Yoshino, M., Kajitani, T., Okada, K., and Miyamoto, K.: Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. (2003) Gene 302, 83-94 (PDF).
      39. Onuma, H., Osawa, H., Yamada, K., Ogura, T., Tanabe, F., Granner, D. K., and Makino, H.: Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein. (2002) Diabetes 51, 3362-3367.
      40. Sekiguchi, T., Mizutani, T., Yamada, K., Yazawa, T., Kawata, H., Yoshino, M., Kajitani, T., Kameda, T., Minegishi, T., and Miyamoto, K.: Transcriptional regulation of the Epiregulin gene in the rat ovary. (2002) Endocrinol. 143, 4718-4729.
      41. Yamada, K., Kawata, H., Matsuura K., Shou, Z., Hirano, S., Mizutani, T., Yazawa, T., Yoshino, M., Sekiguchi, T., Kajitani, T., and Miyamoto, K.: Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). (2002) Biochem. Biophys. Res. Commun. 297, 368-374 (PDF).
      42. Hirano, S., Yamada, K., Kawata, H., Shou, Z., Mizutani, T., Yazawa, T., Kajitani, T., Sekiguchi, T., Yoshino, M., Shigematsu, Y., Mayumi, M., and Miyamoto, K.: Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. (2002) Gene 290, 107-114 (PDF).
      43. Kamataki, A., Takahashi, S., Masamura, K., Iwasaki, T., Hattori, H., Naiki, H., Yamada, K., Suzuki, J., Miyamori, I., Sakai, J., Fujino, T., and Yamamoto, T.: Remnant lipoprotein particles are taken up into myocardium through VLDL receptor- a possible mechanism for cardiac fatty acid metabolism. (2002) Biochem. Biophys. Res. Commun. 293, 1007-1013.
      44. Yoshino, M., Mizutani, T., Yamada, K., Tsuchiya, M., Minegishi, T., Yazawa, T., Kawata, H., Sekiguchi, T., Kajitani, T., and Miyamoto, K.: Early growth response gene-1 (Egr-1) regulates the expression of the luteinizing hormone receptor gene. (2002) Biol. Reprod. 66, 1813-1819.
      45. Kikkawa, E., Hinata, M., Keng, V. W., Myint, Z., Sato, A., Yamada, K., Tanaka, T., and Noguchi, T.: Sp family members stimulate the transcription of Hex gene via interactions with GC boxes. (2001) J. Biochem. (Tokyo) 130, 885-891.
      46. Mizutani, T., Yamada, K., Yazawa, T., Okada, T., Minegishi, T., and Miyamoto, K.: Cloning and characterization of gonadotropin inducible ovarian transcription factors (GIOT1 and 2) that are novel members of the (Cys)2-(His)2-type zinc finger protein family. (2001) Mol. Endocrinol. 15, 1693-1705.
      47. Shimada, N., Yamada, K., Tanaka, T., Kawata, H., Mizutani, T., Miyamoto, K., and Matsuzawa, T.: Alterations of gene expression in endoderm differentiation of F9 teratocarcinoma cells. (2001) Mol. Reprod. Dev. 60, 165-171 (PDF).
      48. Niiya, T., Osawa, H., Onuma, H., Suzuki, Y., Taira, M., Yamada, K., and Makino, H.: Activation of mouse phosphodiesterase 3B gene promoter by adipocyte differentiation in 3T3-L1 cells. (2001) FEBS Lett. 505, 136-140.
      49. Sekiguchi, T., Miyamoto, K., Mizutani, T., Yamada, K., Yazawa, T., Yoshino, M., Minegishi, T., Takei, Y., Kangawa, K., Minamino, N., Saito, Y., and Kojima, M.: Molecular cloning of natriuretic-peptide receptor A from bull frog (Rana catesbeiana) brain and its functional expression. (2001) Gene 273, 251-257.
      50. Miyamoto, K., Morishita, Y., Yamazaki, M., Minamino, N., Kangawa, K., Mizutani, T., Yamada, K., and Minegishi, T.: Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid, and its cDNA cloning from bovine and human ovary. (2001) Arch. Biochem. Biophys. 390, 93-100.
      51. Yamada, K., Mizutani, T., Shou, Z., Yazawa, T., Sekiguchi, T., Yoshino, M., Inazu, T., and Miyamoto, K.: Cloning and functional expression of an E box-binding protein from rat granulosa cells. (2001) Biol. Reprod. 64, 1315-1319 (PDF).
      52. Keng, V. W., Yagi, H., Ikawa, M., Nagano, T., Myint, Z., Yamada, K., Tanaka, T., Sato, A., Muramatsu, I., Okabe, M., Sato, M., and Noguchi, T.: Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. (2000) Biochem. Biophys. Res. Commun. 276, 1155-1161.
      53. Mizutani, T., Yamada, K., Minegishi, T., and Miyamoto, K.: Transcriptional regulation of rat scavenger receptor class B type I gene. (2000) J. Biol. Chem. 275, 22512-22519.
      54. Wang, J.-C., Waltner-Law, M., Yamada, K., Osawa, H., Stifani, S., and Granner, D. K.: Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3b. (2000) J. Biol. Chem. 275, 18418-18423.
      55. Yamada, K., Tanaka, T., Miyamoto, K., and Noguchi, T.: Sp family members and nuclear factor-Y cooperatively stimulate transcription from the rat pyruvate kinase M gene distal promoter region via their direct interactions. (2000) J. Biol. Chem. 275, 18129-18137 (PDF).
      56. Inazu, T., Yamada, K., and Miyamoto, K.: Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family. (1999) Biochem. Biophys. Res. Commun. 265, 87-93.
      57. Yamada, K., Osawa, H., and Granner, D. K.: Identification of proteins that interact with NF-YA. (1999) FEBS Lett. 460, 41-45 (PDF).
      58. Yamada, K., Printz, R. L., Osawa, H., and Granner, D. K.: Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. (1999) Biochem. Biophys. Res. Commun. 261, 614-621 (PDF).
      59. Myint, Z., Inazu, T., Tanaka, T., Yamada, K., Keng, V. W., Inoue, Y., Kuriyama, M., and Noguchi, T.: Genomic organization and promoter analysis of a mouse homeobox gene, Hex. (1999) J. Biochem. (Tokyo) 125, 795-802.
      60. Yamada, K., Tanaka, T., and Noguchi, T.: Characterization and purification of carbohydrate response element-binding protein of the rat L-type pyruvate kinase gene promoter. (1999) Biochem. Biophys. Res. Commun. 257, 44-49 (PDF).
      61. Tanaka, T., Inazu, T., Yamada, K., Myint, Z., Keng, V. W., Inoue, Y., Taniguchi, N., and Noguchi, T.: cDNA cloning and expression of rat homeobox gene, Hex and functional characterization of the protein. (1999) Biochem. J. 339, 111-117.
      62. Yamada, K., Duong, D. T., Scott, D. K., Wang, J.-C., and Granner, D. K.: CCAAT/ Enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter. (1999) J. Biol. Chem. 274, 5880-5887 (PDF).
      63. Yamada, K., Wang, J.-C., Osawa, H., Scott, D. K., and Granner, D. K.: Efficient large-scale transformation of yeast. (1998) BioTechniques 24, 596-600.
      64. Watanabe, D., Yamada, K., and Matsuzawa, T.: Chromosome features in the endodermal differentiation of mouse embryonal carcinoma-derived F9 cells; increased sister-chromatid exchanges and the direct assay for DNA methylation. (1998) Memoirs of Osaka Kyoiku University 46, 257-269.
      65. Yamada, K., Tanaka, T., and Noguchi, T.: Members of the nuclear factor 1 family and hepatocyte nuclear factor 4 bind to overlapping sequences of the L-II element on the rat pyruvate kinase L gene promoter and regulates its expression. (1997) Biochem. J. 324, 917-925.
      66. Takenaka, M., Yamada, K., Lu, T., Kang, R., Tanaka, T., and Noguchi, T.: Alternative splicing of the pyruvate kinase M gene in a minigene system. (1996) Eur. J. Biochem. 235, 366-371.
      67. Kang, R., Yamada, K., Tanaka, T., Lu, T., and Noguchi, T.: Relationship between the concentrations of glycolytic intermediates and expression of the L-type pyruvate kinase gene in cultured hepatocytes. (1996) J. Biochem. (Tokyo) 119, 162-166.
      68. Uenaka, R., Nakajima, H., Noguchi, T., Imamura, K., Hamaguchi, T., Tomita, K., Yamada, K., Kuwajima, M., Kono, N., Tanaka, T., and Matsuzawa, Y.: Compound heterozygous mutations affecting both hepatic and erythrocyte isozymes of pyruvate kinase. (1995) Biochem. Biophys. Res. Commun. 208, 991-998.
      69. Wang, Z., Takenaka, M., Imai, E., Yamada, K., Tanaka, T., and Noguchi, T.: Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene. (1994) Eur. J. Biochem. 220, 301-307.
      70. Watanabe, D., Yamada, K., Nishina, Y., Tajima, Y., Koshimizu, U., Nagata, A., and Nishimune, Y.: Molecular cloning of a novel Ca2+-binding protein (Calmegin) specifically expressed during male meiotic germ cell development. (1994) J. Biol. Chem. 269, 7744-7749.
      71. Noguchi, T., Matsuda, T., Tomari, Y., Yamada, K., Imai, E., Wang, Z., Ikeda, H., and Tanaka, T.: The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat. (1993) FEBS Lett. 328, 145-148.
      72. Noguchi, T., Okabe, M., Wang, Z., Yamada, K., Imai, E., and Tanaka, T.: An enhancer unit of L-type pyruvate kinase gene is responsible for transcriptional stimulation by dietary fructose as well as glucose in transgenic mice. (1993) FEBS Lett. 318, 269-272.
      73. Yamada, K., Uemura, M., and Matsuzawa, T.: Increase of specific activity, electrophoretic type-transition and gene expression of alkaline phosphatase during endodermal differentiation of F9 mouse embryonal carcinoma cells. (1992) Develop. Growth & Diff. 34, 9-16.
      74. Noguchi, T., Yamada, K., Yamagata, K., Takenaka, M., Nakajima, H., Imai, E., Wang, Z., and Tanaka, T.: Expression of liver type pyruvate kinase in insulinoma cells: involvement of LF-B1 (HNF1). (1991) Biochem. Biophys. Res. Commun. 181, 259-264.
      75. Yamasaki, T., Nakajima, H., Kono, N., Hotta, K., Yamada, K., Kuwajima, M., Noguchi, T., Tanaka, T., and Tarui, S.: Structure of the entire human muscle phosphofructokinase-encoding gene: a two-promoter system. (1991) Gene 104, 277-282.
      76. Takenaka, M., Noguchi, T., Sadahiro, S., Hirai, H., Yamada, K., Matsuda, T., Imai, E., and Tanaka, T.: Isolation and characterization of the human pyruvate kinase M gene. (1991) Eur. J. Biochem. 198, 101-106.
      77. Imai, E., Noguchi, T., Takenaka, M., Yamada, K., Matsuda, T., Monaci, P., Nicosia, A., and Tanaka, T.: Alteration in L-type pyruvate kinase gene expression is not associated with the LF-B1 mRNA level. (1991) Biochem. Biophys. Res. Commun. 176, 1074-1078.
      78. Yamada, K., Noguchi, T., Matsuda, T., Takenaka, M., Monaci, P., Nicosia, A., and Tanaka, T.: Identification and characterization of hepatocyte-specific regulatory regions of the rat pyruvate kinase L gene. (1990) J. Biol. Chem. 265, 19885-19891 (PDF).
      79. Matsuda, T., Noguchi, T., Yamada, K., Takenaka, M., and Tanaka, T.: Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates. (1990) J. Biochem. (Tokyo) 108, 778-784.
      80. Yamada, K., Noguchi, T., Miyazaki, J., Matsuda, T., Takenaka, M., Yamamura, K., and Tanaka, T.: Tissue-specific expression of rat pyruvate kinase L/chloramphenicol acetyltransferase fusion gene in transgenic mice and its regulation by diet and insulin. (1990) Biochem. Biophys. Res. Commun. 171, 243-249.
      81. Matsuda, T., Noguchi, T., Takenaka, M., Yamada, K., and Tanaka, T.: Regulation of L-type pyruvate kinase gene expression by dietary fructose in normal and diabetic rats. (1990) J. Biochem. (Tokyo) 107, 655-660.
      82. Noguchi, T., Takenaka, M., Yamada, K., Matsuda, T., Hashimoto, M., and Tanaka, T.: Characterization of the 5′ flanking region of rat glucokinase gene. (1989) Biochem. Biophys. Res. Commun. 164, 1247-1252.
      83. Takenaka, M., Noguchi, T., Inoue, H., Yamada, K., Matsuda, T., and Tanaka, T.: Rat pyruvate kinase M gene: its complete structure and characterization of the 5′-flanking region. (1989) J. Biol. Chem. 264, 2363-2367.
      84. Noguchi, T., Yamada, K., Inoue, H., Matsuda, T., and Tanaka, T.: The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. (1987) J. Biol. Chem. 262, 14366-14371.